Evaluation of Exhaled Nitric Oxide in Schoolchildren at Different Exhalation Flow Rates

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Comparison of measured exhaled nitric oxide at varying flow rates.

nitric oxide at varying flow rates Altered levels of exhaled nitric oxide (FeNO) have been well documented in a number of conditions, although it is in asthma that this phenomenon has been most extensively investigated. Raised FeNO levels in patients with asthma have been correlated not only with other markers of airway inflammation (including induced sputum eosinophil count), but also with air...

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Exhalation flow and pressure-controlled reservoir collection of exhaled nitric oxide for remote and delayed analysis.

BACKGROUND Expiratory flow rate, soft palate closure, and dead space air may influence exhaled levels of nitric oxide (NO). These factors have not been evaluated in the reservoir collection of NO. METHODS Exhaled NO was collected into a reservoir during a single flow and pressure controlled exhalation. RESULTS NO collected in a reservoir containing silica gel was stable for 24 hours. Nasall...

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Impact of analysis interval on the multiple exhalation flow technique to partition exhaled nitric oxide.

Exhaled nitric oxide (eNO) is elevated in asthmatics and is a purported marker of airway inflammation. By measuring eNO at multiple flows and applying models of eNO exchange dynamics, the signal can be partitioned into its proximal airway [J' aw NO (nl/sec)] and distal airway/alveolar contributions [CA(NO)(ppb)]. Several studies have demonstrated the potential significance of such an approach i...

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Multiple flow rates measurement of exhaled nitric oxide in patients with sarcoidosis: a pilot feasibility study.

Fraction of end tidal exhaled nitric oxide (FeNO) has been introduced as a non-invasive marker of airway inflammation in patients with asthma and may have value in monitoring disease activity in patients with sarcoidosis. This pilot study explored: 1) feasibility of the multiple flow rates maneuver to estimate alveolar (C(AlV)NO) and airway wall (J(AW)NO) NO in patients with sarcoidosis; and 2)...

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Nasal contribution to exhaled nitric oxide during exhalation against resistance or during breath holding.

BACKGROUND The concentration of nitric oxide (NO) is increased in the exhaled air of patients with inflammation of the airways, suggesting that this may be a useful measurement to monitor inflammation in diseases such as asthma. However, there have been concerns that exhaled NO may be contaminated by the high concentrations of NO derived from the upper airways, and that this may account for dif...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 2002

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-200209000-00015